Healthy Literature
多酚和類胡蘿蔔素對年齡相關性眼睛疾病的健康益處
Health Benefits of Polyphenols and Carotenoids in Age-Related Eye Diseases.
/ 文獻筆記 /
氧化壓力和炎症在年齡相關性眼部病變的發生和過程有著關鍵作用，如白內障，青光眼，糖尿病性視網膜病變和退化性黃斑部病變等；如何改善及預防，一直是大家所關注的健康焦點。近年來多被關注的植化素(例如:類胡蘿蔔素（carotenoids）、多酚類（polyphenols）)是已被證實其抗氧化及抗炎活性，對這些疾病是有預防效果的。且根據彙整研究調查多酚(如:花青素)和類胡蘿蔔素(如:葉黃素)對於治療與年齡相關退化性眼睛疾病，具有顯著的改善及預防效果；主要的原因是多酚和類胡蘿蔔素具有協同作用增加了抗氧化及抗炎的活性。
Oxidative stress and inflammation play a critical role in the initiation and progression of age-related ocular abnormalities as cataract, glaucoma, diabetic retinopathy, and macular degeneration. Therefore, phytochemicals with proven antioxidant and anti-inflammatory activities, such as carotenoids and polyphenols, could be of benefit in these diseases. We searched PubMed and Web of Science databases for original studies investigating the benefits of different carotenoids and polyphenols in age-related ophthalmic diseases. Our results showed that several polyphenols (such as anthocyanins, Ginkgo biloba, quercetin, and resveratrol) and carotenoids (such as lutein, zeaxanthin, and mezoxanthin) have shown significant preventive and therapeutic benefits against the aforementioned conditions. The involved mechanisms in these findings include mitigating the production of reactive oxygen species, inhibiting the tumor necrosis factor-α and vascular endothelial growth factor pathways, suppressing p53-dependent apoptosis, and suppressing the production of inflammatory markers, such as interleukin- (IL-) 8, IL-6, IL-1a, and endothelial leucocyte adhesion molecule-1. Consumption of products containing these phytochemicals may be protective against these diseases; however, adequate human data are lacking. This review discusses the role and mechanisms of polyphenols and carotenoids and their possible synergistic effects on the prevention and treatment of age-related eye diseases that are induced or augmented by oxidative stress and inflammation.—文獻摘要
Oxid Med Cell Longev. 2019 Feb 12;2019:9783429. doi: 10.1155/2019/9783429. eCollection 2019—文獻出處
https://www.ncbi.nlm.nih.gov/pubmed/30891116 文獻連結
